This is where Runewords are available. Similar to the many gems you'll find, runes are able to be placed into sockets to provide beneficial effects. But if specific runes are put into items in a particular D2R Items order you'll activate the runeword. Runeword.
The ability activates crucial effects that go beyond the scope of what the individual runes normally provide. For example, Enigma provides +1 to Teleport which is a special skill for Sorcerers that Enigma makes available to such as Paladins that allows for something like the extremely deadly Hammerdin build to achieve its full potential.
There are Runeword lists on the internet in the game's original version, but a crucial factor to be aware of is that they are just compatible for items with gray text. As an example, magical items, which are marked by their blue text do not support Runewords. However, the stats of the item are useful for making the most of a runeword Don't be quick to throw runes into the first item that has sockets you find.
In the beginning of the buy diablo 2 resurrected items game, farming the Countess in Act 1 is a good way to acquire runes. This can aid in building some of the Runewords at the lower levels that are available, like Stealth (Tal + Eth; boosts to movement speed, mana recovery, and more) in addition to Leaf (Tir + Ral; gives a range of useful skills to Sorcerers).